Wednesday, October 15, 2008

Uncovering the origins and diversity of the E1-superfamily of proteins

The E1-superfamily of proteins are central to ubiquitin (Ub) conjugation, biosynthesis of cysteine, thiamine and MoCo and several secondary metabolites. Yet the diversity and evolutionary history of these proteins was poorly understood. Recently, we undertook a comprehensive study of the E1 superfamily and uncovered several interesting and surprising insights.

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